abstract |
The present invention provides novel compounds that are regulators of γ-secretase. The compound has the formula (I). Also disclosed are methods of modulating gamma secretase activity using compounds of formula (I) and methods of treating Alzheimer's disease. The invention includes (1) modulating γ-secretase, or (2) treating one or more neurodegenerative diseases, or (3) amyloid protein in, on or around neural tissue (eg, brain) ( For example, combination therapy to inhibit (amyloid β protein) deposition or (4) to treat Alzheimer's disease is also provided. |