| abstract |
The present application provides the amino acid and nucleic acid sequences of the heavy and light chain complementarity determining regions of cancer specific antibodies to the epitope of mutant heterologous ribonucleoprotein G (HnRNPG). In addition, the present application provides immunoconjugates comprising cancer specific antibodies and cancer specific antibodies attached to a toxin or label, and methods of use thereof. The application also relates to diagnostic methods and kits using the cancer specific antibodies disclosed herein. In addition, the present application provides novel cancer associated epitopes and antigens of mutant HnRNPG and uses thereof. |