| abstract |
Various compounds containing a thiazolidine ring and the use of such compounds to inhibit at least one BCL-2 protein family member are described. One of the compounds described has the structure A, wherein each of R 1 and R 2 is hydrogen, substituted or unsubstituted straight chain aliphatic group, halogen, alkoxyl, halogen substituted alkyl, halogen substituted alkoxyl , Hydroxyl, carboxyl, cyano group, amide group, substituted or unsubstituted alicyclic group, substituted or unsubstituted aromatic group, or substituted or unsubstituted heterocyclic group; X represents an oxygen, sulfur, or imino group Including; Z includes in particular moieties such as naphthalene or dehydronaphthalene. |