| abstract |
New prodrugs of baclofen and baclofen analogues that are well absorbed in the large intestine / colon and are therefore suitable for oral sustained release formulations, thereby improving the convenience, efficacy and side effect profile of baclofen treatment Drag offer. An acyloxyalkyl carbamate prodrug of (±) 4 amino 3 (4 fluorophenyl) butanoic acid and its analogs represented by the following formula: (Wherein R5 is 4-fluorophenyl) and pharmaceutical compositions thereof, methods of making prodrugs of (±) 4 amino 3 (4 fluorophenyl) butanoic acid and analogs, spasticity and / or acid A method of using a prodrug of (±) 4 amino 3 (4 fluorophenyl) butanoic acid and its analogs to treat or prevent common diseases and / or symptoms such as reflux disease. [Selection figure] None |