| abstract |
Methods and reagents for modulating smoothened dependent pathway activity are provided. Steroidal alkaloids and their analogs are used to suppress phenotypic effects of unwanted activity in the hedgehog pathway resulting from mutations in hedgehog hyperactivity, ptc dysfunction or smoothened hyperfunction Method. The method preferably comprises neural tissue regulation, bone and cartilage formation and repair, spermatogenesis regulation, smooth muscle regulation, smooth muscle regulation, lung, liver and gastrointestinal regulation, hematopoietic function regulation, and skin And used to regulate hair growth. [Selection figure] None |