| abstract |
The present invention provides a novel low molecular weight compound that suppresses the production of inducible MMPs, particularly MMP-9, rather than the production of constitutive MMP-2, and at the same time, the preventive / therapeutic agent for autoimmune disease or osteoarthritis. I will provide a. The following formula (I) (In the formula, each symbol is as defined in the specification.) As an active ingredient, an amide derivative represented by the formula, a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof is contained. Pharmaceutical composition. [Selection figure] None |