| abstract |
Disclosed is a compound having eNOS activity that can maintain vascular function in a healthy state while preventing endothelial dysfunction, can be taken orally, and is safe even if taken continuously for a long period of time. An imidazolone derivative of the formula (1). (R 1 represents a hydrogen atom or a C 1-10 alkyl group; R 2 represents a C 1-10 alkyl group having one or more hydroxy groups; and R 3 represents an amino group and / or a carboxyl group. An optionally substituted C 1-10 alkyl group, provided that R 1 is a hydrogen atom and R 3 is — (CH 2 ) 3 —CH (NH 2 ) CO 2 H; R 2 is not a 2,3,4-trihydroxybutyl group.) Or a salt thereof. [Selection figure] None |