abstract |
A method for reducing scarring is provided. The method includes administering a polynucleotide comprising an expression cassette to the skin of a subject having a wound, wherein the expression cassette is operably linked to a polynucleotide encoding p21 WAF1 / Cip1. An enhanced promoter. In one aspect, the DNA is administered as part of a vector. In one aspect, the vector is a viral vector. In one aspect, the viral vector is an adenoviral vector. In one aspect, the adenoviral vector is a replication-defective adenoviral vector. In one aspect, the administering step results in a decrease in keloid or hypertrophic scar in the wound compared to scar in an untreated wound. [Selection] Figure 1A |