| abstract |
The present invention provides compounds, compositions and methods for modulating the activity of nuclear receptors (including farnesoid X receptor and / or orphan nuclear receptor). Formula (I) or a pharmaceutically acceptable derivative thereof; wherein: R 1 is —C (J) OR 14 , —C (J) SR 14 and —C (J) N (R 15 ) R 16 ; J is O, S or NR 17 ; R 2 is hydrogen, halo or optionally substituted alkyl; R 3 is —C (O); 9 , R 4 , R 5 , R 6 and R 7 and R 8 represent a substituent. [Selection figure] None |