| abstract |
A cosmetic and an external preparation for skin that can effectively prevent or improve the generation of wrinkles. The present invention provides a cosmetic and an external preparation for skin containing at least one moisturizing ingredient selected from the group consisting of soybean, toki, mushroom, hikikoshi, yashabushi and valine, and a synthetic peptide having an anti-wrinkle action. . In this cosmetic and external preparation for skin, the synthetic peptide can have, for example, an activity that competitively inhibits the binding of agrin to muscle-specific kinase (MuSK). [Selection figure] None |