| abstract |
Disclosed are a method for treating a neurological disease and a pharmaceutical composition for treating chronic pain. Intrathecal injection of an effective amount of double-stranded (ds) RNA. This dsRNA inhibits the expression of the target gene. In one preferred embodiment, the chronic pain is chronic neuropathic pain, and in another preferred embodiment, the chronic pain is selected from the group consisting of cancer pain, osteoarthritic pain, allodynia or hyperalgesia. . In a preferred embodiment, the neurological disease is selected from the group consisting of Alzheimer's disease, Parkinson's disease, multiple sclerosis, schizophrenia, epilepsy, depression and pain. [Selection figure] None |