| abstract |
Disclosed is a molecule that inhibits binding of Nogo receptor-1 to its ligand and attenuates myelin-mediated growth cone collapse and inhibition of neurite outgrowth. An immunogenic Nogo receptor-1 polypeptide, a Nogo receptor-1 antibody, an antigen-binding fragment thereof, a soluble Nogo receptor and fusion proteins thereof, and a nucleic acid encoding the same are disclosed. Also disclosed are compositions comprising such Nogo receptor antibodies, antigen binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, and nucleic acids encoding the same, and methods for making and using the same. [Selection figure] None |