| abstract |
Disclosed is a conjugate comprising a carrier substituted with one or more moieties having structure (I). A each M is independently, a molecular weight of a more modifier 10 kDa, represents a direct or indirect binding of M to linker L M, each L M is independently required A succinamide-containing linker which is substituted according to the formula, whereby the modifying substance M is directly or indirectly linked to the succinamide linker via an amide bond, and the carrier is linked via an ester bond. To each succinamide linker directly or indirectly. In other aspects, the present invention provides compositions comprising the conjugates, methods for making the conjugates, and uses of the conjugates in the treatment of various disorders, including but not limited to cancer. [Selection] Figure 8 |