| abstract |
An object of the present invention is to provide a granulated product as an oral solid preparation containing an HMG-CoA reductase inhibitor having excellent temporal stability. A granulated product obtained by granulating a HMG-CoA reductase inhibitor or a mixture of the drug and a basic amino acid with a gastric polymer. The HMG-CoA reductase inhibitor is preferably selected from the group consisting of fluvastatin, atorvastatin, pitavastatin, rosuvastatin and salts thereof. The basic amino acid is preferably arginine, lysine or histidine. The gastric polymer is preferably polyvinyl acetal diethylaminoacetate or aminoalkyl methacrylate copolymer. [Selection figure] None |