| abstract |
[PROBLEMS] To provide a bisphosphonate that is excellent in percutaneous absorption, is safe and easy to use, and is suitable for the treatment of bone calcium metabolic diseases such as osteoporosis, bone Paget's disease, and hypercalcemia associated with malignant tumors. PROBLEM TO BE SOLVED: To provide a tape-type transdermally absorbable preparation comprising a hydrophilic drug layer containing a pharmaceutically effective amount of bisphosphonate on a support sheet, and on the drug layer It is comprised from the provided adhesive hydrophobic surface layer. The base of the hydrophilic drug layer is a hydrophilic acrylic copolymer synthesized from a monomer mixture mainly composed of 50 to 100% acrylic acid and 0 to 40% by weight of acrylic ester. The hydrophobic surface layer was a hydrophobic acrylic pressure-sensitive adhesive synthesized from a monomer mixture mainly composed of an acrylic alkyl ester, and retained cholesterol and an antioxidant. [Selection figure] None |