abstract |
Disclosed is a therapeutic agent that can be used to treat Ig (immunoglobulin) A1 deposition disease. A nucleic acid molecule comprising a first DNA sequence encoding a bacterial IgA1 protease and a second DNA sequence encoding a tag, wherein the second DNA sequence is located upstream of the DNA sequence encoding the IgA1 protease cleavage site. A nucleic acid molecule characterized by: Also use of the IgA1 protease to treat IgA1 deposition in tissues and organs. Since bacterial IgA1 protease specifically cleaves IgA1 molecules, it specifically cleaves and removes IgA1 deposits. It is also a treatment for treating IgA nephropathy, herpes zoster (DH), and Henoch-Schönlein purpura (HS). [Selection figure] None |