| abstract |
Disclosed is an aerosol composition which uses hydrofluoroalkane (HFA) as a propellant and has a sufficient shelf life. In a solution of a liquefied HFA propellant, a co-solvent selected from an amino-type pharmaceutical having a functional group sensitive to oxidation and / or hydrolysis reaction, a pharmaceutically acceptable alcohol [wherein The pH of the solution is adjusted between 2.5 and 5.0 by the addition of a small amount of an inorganic acid such as hydrochloric acid, nitric acid or phosphoric acid]. The solution preferably contains low volatile components with a vapor pressure not exceeding 0.1 kPa, preferably not exceeding 0.05 kPa at 25 ° C. The low volatile component is preferably isopropyl myristate. The auxiliary solvent is preferably ethanol. The active ingredient is preferably salbutamol, salmeterol or the like. [Selection figure] None |