| abstract |
The present invention provides a method for increasing the white blood cell count of an animal subject using a compound of formula (1). These compounds have the formula Z-linker-Z ′ or a pharmaceutically acceptable salt thereof, wherein Z is 9-32 wherein 3-8 of the ring members are nitrogen atoms. A cyclic polyamine comprising a plurality of ring members, wherein the nitrogen atoms are separated from each other by at least two carbon atoms, wherein the heterocycle optionally comprises further heteroatoms in addition to nitrogen. And / or fused to a further ring system; Z ′ is as defined above for Z or is of the formula —N (R) — (CR 2 ) n —X, wherein each R is independently H or linear, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring including a heteroaromatic ring Or mercaptan. [Selection] Figure 1 |