| abstract |
The present invention provides a stable concentrated preparation of a protein or antibody such as natalizumab, which retains the activity of an antibody, can be administered in a small amount, and can be administered to a subject with variable body weight in need thereof. . A stable aqueous formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer that inhibits oxidation of polysorbate, and a method of preparing the formulation. Also, a preparation containing a high concentration of antibody that can be used for patients who maintain a constant volume and have variable body weight. [Selection figure] None |