| abstract |
The present invention provides a novel combination of a selective and specific sinoatrial node If current inhibitor and an agent that inhibits angiotensin converting enzyme. A selective and specific sinoatrial node If current inhibitor (ivabradine, ie 3- {3-[{[(7S) -3,4-dimethoxybicyclo [4.2.0] octa-1,3 , 5-Trien-7-yl] methyl} (methyl) amino] propyl} -7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one or its hydration , A crystalline form or an addition salt with a pharmaceutically acceptable acid) and an agent that inhibits angiotensin converting enzyme (perindopril, or a hydrate thereof, a crystalline form or a pharmaceutically acceptable base) And one of the addition salts). [Selection figure] None |