| abstract |
The present invention provides novel compounds that reduce the level of inflammatory cytokines. Formula (I): In the formula, Y is an oxygen atom or H 2 , R 1 and R 2 are independently a hydrogen atom, a halogen, an alkyl group, an alkoxy group, etc., and R 3 is a hydrogen atom, an alkyl group or a benzyl group. 1-oxo and 1,3-dioxo-2- (2,6-dioxopiperidin-3-yl) isoindoline shown. Further, a method of reducing the levels of tumor necrosis factor α and other inflammatory cytokines by administering such a derivative and a pharmaceutical composition comprising such a derivative to a mammal. [Selection figure] None |