http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011039072-A

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filingDate 2010-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd5cc5986b0bf0263010d1251dc03804
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publicationDate 2011-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2011039072-A
titleOfInvention Detection of therapeutic antibodies in laboratory animals
abstract A method for detecting a therapeutic antibody in a sample obtained from a laboratory animal is provided. (A) preparing a sample to be analyzed; (b) incubating the sample with an antibody that binds to a therapeutic antibody and does not bind to an immunoglobulin of a laboratory animal; (c) optionally, the sample Incubating with a reagent suitable for selectively detecting total therapeutic antibody, active therapeutic antibody, or antigen-binding therapeutic antibody, and (d) treating the complex formed in (b) or (c) Correlating with antibody concentration. A monoclonal antibody (MAB-M-R10Z8E9) against a specific epitope that is present in all types of human immunoglobulin class G but not present in the immunoglobulins of all laboratory animals except chimpanzee IgG is used. [Selection figure] None
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