| abstract |
The present invention provides a synthetic derivative of formula (A) of natural tubulin having high cytotoxicity. [Solution] Wherein B is selected from CH 2 , CH 2 —CH 2 or CH 2 —CH 2 —CH 2 , D is an aromatic linking group, X 1 is alkyl or alkenyl, and X 2 is aryl , Heteroaryl, etc., X 3 is selected from H or together with X 4 forms the group = O, X 4 is H, X 5 is alkylene, R 6 and R 7 are aryl X 8 is selected from H, halogen, etc. [Selection figure] None |