abstract |
[PROBLEMS] To investigate temporal changes in intracellular IL-5 and screen for substances that affect intracellular IL-5 production without providing a process for treating cells or using an antibody. A test material and a test method are provided. A transgenic non-human mammal, an embryonic stem cell used for production thereof, and a production method thereof, comprising a fluorescent protein gene in the reading frame of exon 1 of interleukin-5 gene. Furthermore, a method of screening for a substance that affects IL-5 gene expression using the animal or cell. [Selection figure] None |