abstract |
Disclosed is a novel compound having optimal characteristics of cytotoxicity and selectivity for tumors, reduced systemic toxicity, and improved pharmacokinetic properties. General formula I: [Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are H, OH, OR ′, SH, SR ′, SOR ′, SO 2 R ′, C (═O) R ′, C (═O) OR ′, NO 2 , NH 2 , NHR ′, N (R ′) 2 , NHC (O) R ′, CN, halogen, ═O, etc., each individually selected; X is , OR ′, CN, (═O), or H, each R ′ group is H, OH, NO 2 , NH 2 , SH, CN, halogen, ═O, C (═O) H , C (═O) CH 3 , CO 2 H, etc., each individually selected; m is 0, 1, or 2; and n is 0, 1, 2, 3, or 4 A derivative of echinasaidin 736. [Selection figure] None |