| abstract |
The present invention provides a pharmaceutical effective as a renin inhibitor. A pharmaceutical comprising a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein R 1 a is a halogen atom or the like; R 1m is a hydrogen atom or the like; G 1 is —N (R 1b ) —. G 2 is —CO— or the like; G 3 is —C (R 1c ) (R 1d ) — or the like; G 4 is an oxygen atom or the like; R 1b is an optionally substituted C 1-6 alkyl group or the like; R 1c and R 1d are each independently the same or different and are a hydrogen atom or the like; R 2 is a hydrogen atom, an optionally substituted C 1-6 alkyl group or the like; R 3a , R 3b , R 3c , And R 3d are each independently the same or different and are a group: -AB (wherein A is a single bond or the like, B is a hydrogen atom or the like); and n is 1 , Etc. ] [Selection figure] None |