| abstract |
PROBLEM TO BE SOLVED: To provide optimal administration of 2'-branched nucleosides, particularly 2'-branched pyrimidine nucleosides, for optimizing treatment of HCV infection and treating flaviviridae virus infection. Mutations at positions other than nucleotide mutations that result in a change from serine to another amino acid in the highly conserved consensus sequence XRXSGXXXT of domain B of the RNA polymerase region in the Flaviviridae virus in a flaviviridae virus in humans in need of treatment In combination or alternation with one or more drugs that directly or indirectly induce and / or one or more drugs involved in such mutations, 2'-branched nucleosides or pharmaceutically acceptable salts, esters or pros thereof A method for treating a Flaviviridae viral infection comprising administering a drug. A method for detecting a mutant strain of Flaviviridae virus and a method for this treatment are also included. [Selection figure] None |