| abstract |
Disclosed is a novel compound useful as a modulator of a KCNQ channel. A compound represented by the following formula useful as a modulator of a KCNQ channel. (R1 is —CN; R2 is halo, haloalkyl, hydroxy or alkoxy; X is NR ″ or NR ″ CH2; R ″ is H; R4 is aryl-alkyl, the group consisting of halo or methylenedioxy Is mono- or poly-substituted by a substituent selected from the group; or R4 is of the formula -Z'-L "-Z", in which Z 'and Z "are independently of each other aryl. And may be mono- or poly-substituted by halo, and L ″ represents a single (covalent) bond or a bridging group selected from O or OCH 2; provided that when X is NR ″, R4 represents aryl-alkyl, and when X is NR ″ CH2, R4 represents a group represented by the formula —Z′-L ″ —Z ″. [Selection figure] None |