| abstract |
A novel transporter gene belonging to the OATP family, a protein encoded by the gene, and uses thereof are provided. A novel transporter gene was screened on the basis of the gene sequence of human OATP transporter, and four new transporter genes were successfully cloned. These transporters are useful for the development of drugs that utilize transport activity against biological materials and various drugs. Moreover, it discovered that single nucleotide polymorphism (SNP) exists in these transporter genes. Genetic diagnosis based on these transporter gene polymorphisms (SNP, etc.) makes it possible to determine the effectiveness of drug therapy, for example. [Selection figure] None |