| abstract |
PROBLEM TO BE SOLVED: To provide an improved method for treating a disease state in which a pathogenic cell population such as cancer cells is present. A method for enhancing specific elimination of a population mediated by an endogenous immune response in a pre-immunized host animal that harbors a pathogenic cell population, wherein members of the cell population reach a ligand. Has possible binding sites, Administering to the host a composition containing a hapten conjugated to an immunogen or ligand that is recognized by an endogenous antibody in the host or directly recognized by immune cells in the host. in the method, the immunogen or immunogenic hapten - improving method comprising step of pre-immunization of said host with a carrier conjugate and T H 1 biasing adjuvant derive existing immunity. Preferably, the method further includes the step of administering a therapeutic factor selected from the group consisting of a cell killing agent, a tumor penetration enhancer, a chemotherapeutic agent and the like. [Selection figure] None |