| abstract |
The present invention provides a novel substituted xanthine having an inhibitory effect on the activity of the enzyme dipeptidyl peptidase-IV (DPP-IV). A substituted xanthine of the following general formula (I), a tautomer, stereoisomer, mixture and salt thereof; a pharmaceutical composition comprising the same. (Wherein R represents a specific substituent). The compounds can be used to prepare pharmaceutical compositions suitable for the treatment of type I and type II diabetes, arthritis, obesity, allograft transplantation and calcitonin-induced osteoporosis. [Selection figure] None |