http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011004708-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faf522b8b83eded745c73018576219ba |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2009-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_182e0df46d3d142a268a6b6b9f540917 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92ddc51a5e951fb4972e183660abead7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24448b8e6863f84fdf49f6d039b8ca83 |
| publicationDate | 2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011004708-A |
| titleOfInvention | Method for designing small RNA duplex and hairpin RNA |
| abstract | The present invention relates to a small RNA duplex or hairpin that has high knockdown efficiency not only in tissues with high expression of Ago2 (such as heart and kidney in humans) but also in tissues with low expression of Ago2 (such as liver and pancreas in humans). To provide a method for designing type RNA. SOLUTION: In a complementary double-stranded part of a small RNA duplex or hairpin RNA, the sequence of the side strand (guide strand) that acts by being incorporated into RISC is complementary to the sequence of the mRNA to be targeted. As for the sequence of the strand (passenger strand) on the side that is designed to be high and is eliminated from RISC, it is based on the sequence complementary to the guide strand. 9 to 11) from the position of the passenger strand corresponding to at least one base substitution, introducing mismatch or G: U wobble base pair, and (2) the seed region of the guide strand ( At least one base substitution at the position of the passenger strand corresponding to the second to eighth base from the 5 'end) and / or the 3'-mid region (the 12th to 16th base from the 5'end); Mismatch or G: U A method for designing small RNA duplex or hairpin RNA, which includes introducing wobble base pairs. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017527294-A |
| priorityDate | 2009-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.