| abstract |
The compound of formula (I) is an A 2B receptor antagonist: Wherein R 1 and R 2 are hydrogen or optionally substituted C 1 -C 6 alkyl, C 1 -C 6 alkoxy- (C 1 -C 6 ) -alkyl, C 3 -C 8 cycloalkyl, Independently selected from aryl, heteroaryl, aryl- (C 1 -C 6 ) -alkyl or heteroaryl- (C 1 -C 6 ) -alkyl; or R 1 and R 2 are attached to them Taken together with the nitrogen atom to form an optionally substituted 5- or 6-membered ring; R 3 and R 4 are hydrogen or optionally substituted C 1 -C 6 alkyl, C 1- C 6 alkoxy- (C 1 -C 6 ) -alkyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, aryl- (C 1 -C 6 ) -alkyl or heteroaryl- (C 1 -C 6 )- Independently selected from alkyl; or R 3 and R 4 are optionally substituted together with the nitrogen atom to which they are attached. Or a 6-membered ring; R 5 and R 6 are hydrogen or C 1 -C 6 alkyl, aryl, aryl- (C 1 -C 6 ) -alkyl, —NHR 7 , —N (—R 8 ) -R 9, -NH- (C = O ) -R 10, - (C = O) -NH-R 11, - (C = O) is independently selected from -OR 12 or halo; and R 7, R 8 , R 9 , R 10 , R 11 and R 12 are independently selected from C 1 -C 6 alkyl, aryl, aryl- (C 1 -C 6 ) -alkyl and heteroaryl. [Selection figure] None |