| abstract |
For example, mathematical models and methods (eg, computer-implemented methods) for predicting tumor susceptibility to radiation therapy that can be used to select treatments for subjects with tumors. be written. In one aspect, the present invention predicts the sensitivity of cells (ie, living cells, eg, tumor cells or normal (non-tumor) cells, or cultured cells) to a selected radiotherapy dose. Methods (eg, computer-implemented methods) are provided for. The method includes assigning a radiation sensitivity index to a cell based on the expression level of two or more signature genes in the cell. Here, the radiosensitivity index indicates whether the cell is sensitive to radiotherapy. |