abstract |
In one aspect, the present invention provides compositions and methods for reducing FSH levels in a patient. The patient may, for example, be diagnosed with a FSH related disorder or may desire to delay or inhibit germ cell maturation. In certain aspects, the disclosure provides methods of reducing or inhibiting FSH secretion using a polypeptide comprising a soluble activin-binding ActRIIa polypeptide that binds to activin. In another aspect, the disclosure provides a method of reducing FSH levels in a human subject having a FSH related disorder. |