| abstract |
The present invention relates to modulators of the ATP-binding cassette (“ABC”) transporter or fragments thereof, including cystic fibrosis membrane conductance regulators, compositions thereof, and methods of using the same. The present invention relates to a method of treating ABC transporter mediated diseases using such modulators. Diseases to be treated by the compounds of the present invention include, for example, cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiency, such as protein C deficiency, type 1 hereditary angioedema, etc. Can be mentioned. |