| abstract |
The present invention relates to novel naphthoclass compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors, methods of using such compounds to treat cancer, disorders in mammals associated with abnormal Stat3 pathway activity Relates to methods of using such compounds for the treatment of as well as pharmaceutical compositions comprising such compounds. In one aspect, the invention provides a method of treating a disorder associated with abnormal Stat3 pathway activity in a subject comprising administering to the subject a therapeutically effective amount of a compound of Formulas I-VIII described herein. provide. |