| abstract |
A compound of formula (A) wherein R ′ is hydrogen, —C (O) OA, —C (O) CX 3 , —OHC (O) NH 2 , —C (O) —NHOH or (a) A method for the production of sorafenib or a salt thereof is provided. In addition, intermediate compounds of general formula (A), N-methyl-4- (4-ureidophenoxy) picolinamide, 4- (2- (methylcarbamoyl) pyridin-4-yloxy) phenylcarbamate derivatives and N-methyl -4- (4- (2,2,2-trihaloacetamido) phenoxy) picolinamide, methods for their production, and their use in the production of sorafenib are provided. [Chemical 1] [Selection figure] None |