| abstract |
Provided are dosage forms for sedation and analgesia during treatment, including combinations of opioids such as sufentanil and benzodiazepines such as triazolam, for administration via the oral transmucosal route, and methods of using the same. The In one embodiment, the dosage form of the present invention has a mass of less than 100 mg and comprises from about 5 mcg to about 50 mcg sufentanil and from about 100 mcg to about 500 mcg triazolam. Furthermore, oral transmucosal administration of this solid dosage form to subjects results in a sufentanil T max with an overall mean coefficient of variation of less than 40%. |