http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010532776-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-366 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 |
| filingDate | 2008-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2010532776-A |
| titleOfInvention | Thrombomodulin to increase reperfusion and prevent vascular occlusion |
| abstract | Use of thrombomodulin for the manufacture of a medicament for stimulating reperfusion of ischemic tissues or organs in a patient in need of the medicament, in particular a stroke patient. The thrombolytic effect of thrombomodulin according to one embodiment of the present invention with respect to improved reperfusion was surprisingly found in animal models with stable occlusion of the middle cerebral artery (MCA). Mice with occluded MCA were treated with soluble thrombomodulin and surprisingly exhibited substantial reperfusion as measured by increased cerebral blood flow (CBF). This finding was unexpected because known anticoagulant effects on thrombomodulin from animal studies suggested the ability to prevent blood clotting rather than simply restoring blood flow. |
| priorityDate | 2007-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 182.