| abstract |
The present invention relates to a novel class of 4-carboxybenzylamino derivatives. 4-Carboxybenzylamino compounds can be used to treat cancer. 4-Carboxybenzylamino compounds can also inhibit histone deacetylase and are used to suppress the proliferation of the cells by selectively inducing terminal differentiation and cell growth arrest and / or apoptosis of new cells. Suitable for doing. Thus, the compounds of the present invention are useful for treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the present invention are useful for the prevention and treatment of TRX-mediated diseases such as autoimmune diseases, allergic diseases and inflammatory diseases, and the prevention and / or treatment of central nervous system (CNS) diseases such as neurodegenerative diseases. It appears to be. The invention further provides pharmaceutical compositions containing 4-carboxybenzylamino derivatives and safe dosing regimens for these pharmaceutical compositions that are easy to comply with and that provide therapeutically effective amounts of 4-carboxybenzylamino derivatives in vivo. . |