| abstract |
The present invention modulates the activity of histamine H3 receptors so that histamine H3 receptor related disorders such as cognitive impairment, epilepsy, brain trauma, depression, obesity, sleep and wake disorders such as narcolepsy, shift work syndrome, Attention deficit hyperactivity disorder (ADHD) such as lethargy as a side effect of drug treatment, maintenance of vigilance to help complete work, weakness attacks, hypersomnia, somnolence syndrome, jet lag, sleep apnea , Schizophrenia, allergy, allergic response in upper respiratory tract, allergic rhinitis, nasal congestion, pain, dementia, Alzheimer's disease, etc. (R) -1- {2- [4 '-(3 -Methoxy-propane-1-sulfonyl) -biphenyl-4-yl] -ethyl} -2-methyl-pyrrolidine salt and crystal form and composition thereof It relates. |