| abstract |
The present invention has been found to be a potent modulator of potassium channels and is therefore an important candidate for the treatment of a variety of diseases or disorders such as those responsive to the modulation of potassium channels. Of the novel benzamidine derivatives. Stereoisomer or mixture of stereoisomers thereof, N-oxides thereof, or pharmaceutically acceptable addition salts thereof, B may not be present (ie, no heterocycle is formed) If not present, the nitrogen adjacent to B retains hydrogen (ie “NH”), A represents NH 2 or OH, or B may be present (ie form part of a heterocycle). ), If present, B represents C═O or C═S, A represents NH or O, and the remaining variables are as specified in claim 1. |