abstract |
The present invention has a novel xanthine having a positive allosteric GABAB receptor (GBR) modulator effect, having the general formula (I), wherein R 1 , R 2 , R 3 and R 4 are as defined Compounds, methods of making the compounds, and optionally GABAB agonists for the inhibition of transient lower esophageal sphincter relaxation, the treatment of gastroesophageal reflux disease, and the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS) Relating to their use in combination. [Chemical 1] |