| abstract |
In accordance with the present invention, there are isolated polynucleotide sequences that exhibit endothelial cell specific promoter activity, novel cis-regulators, and methods of their use that allow the treatment of relaxation characterized by abnormal angiogenesis or cell proliferation. Disclosed. Also disclosed by the present invention is an isolated polynucleotide comprising an adenovirus that conditionally replicates linked transcriptionally to a cis-regulator capable of directing transcription in adenovirus angiogenic endothelial cells. . [Selection figure] None |