| abstract |
The present invention has disclosed its use for the production of a functional epitope of osteopontin, a monoclonal antibody that specifically binds to it, an immunoconjugate and its antitumor agent. Furthermore, a sequence encoding the above monoclonal antibody, a vector containing this sequence, and a host cell were disclosed. The monoclonal antibody or immunoconjugate of the present invention is useful for detecting osteopontin. According to the monoclonal antibody or the immunoconjugate of the present invention, the effect of suppressing tumor can be realized by blocking the signal transduction pathway that promotes the metastasis of OPN and preventing the development and metastasis of the tumor. |