| abstract |
The present disclosure relates to synthetic alpha-galactosylceramide (α-GalCer) analogs and their use as immunotherapeutic agents. In one embodiment, a method of activating a cytokine response in a subject comprises a compound of the invention on a subject having an adaptive immune system comprising a cell population comprising at least one lymphocyte and at least one antigen presenting cell. Or administering a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, thereby activating a receptor on the lymphocyte; and lymph Activating the sphere to produce a cytokine response. |