| abstract |
Compound of formula I Wherein A, B, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 have the meanings indicated herein and are class 3 And receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 5 receptor tyrosine kinases). It has also been found that certain compounds of the present invention are inhibitors of Pim-1. In one embodiment, the imidazopyridine compounds of the invention are class 3 receptor tyrosine kinase inhibitors. In certain embodiments, the compound is an inhibitor of class 3 receptor tyrosine kinases PDGFR and FLT3. |