http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010522709-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2010522709-A |
| titleOfInvention | Pyrrole and isoindole carboxamide derivatives as P2X7 modulators |
| abstract | The present invention relates to a compound of formula (I): [Where: R 2 is hydrogen, halogen, C 1-6 alkyl, C 6-10 aryl-methyl -, C 2-6 alkenyl, C 2-6 alkynyl or C 3-6 cycloalkylmethyl - means, said C 1- Any of 6 alkyl, C 6-10 arylmethyl-, C 2-6 alkenyl, C 2-6 alkynyl or C 3-6 cycloalkylmethyl- may be substituted by 1, 2 or 3 halogen atoms Often; R 3 represents hydrogen, fluorine or methyl; Alternatively, R 2 and R 3 together with the carbon atom to which they are attached are selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl and C 2-6 alkynyl, Form a benzene ring optionally substituted by 1, 2 or 3 substituents which may be different] Or a pharmaceutically acceptable salt thereof. The compound or salt thereof can modulate P2X7 receptor function and antagonize the ATP effect at the P2X7 receptor. The invention also provides the use of such compounds or salts or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, such as pain, inflammation or neurodegenerative diseases. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009542595-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016506915-A |
| priorityDate | 2007-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 240.