http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010522158-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-20 |
| filingDate | 2008-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2010522158-A |
| titleOfInvention | Method for producing 2'-deoxy-2 ', 2'-difluorocytidine |
| abstract | 【Task】 The object of the present invention is to provide a process for preparing 2'-deoxy-2 ', 2'-difluorocytidine of formula I in high purity and yield. [Solution] The present invention relates to the preparation of optically pure 3R-hydroxypropanamide compounds of formula VIII from optically active ester compounds of formula IX using chiral amines with optical activity, optically compounds of formula V from compounds of formula VIII. Preparation of pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose compound, glycosylation of a compound of formula V with a nucleobase to form a 2′-deoxy-2 of formula I as a β-nucleoside Disclosed is a method for producing 2'-deoxy-2 ', 2'-difluorocytidine of formula I, comprising producing', 2'-difluorocytidine. According to the invention, optically pure compounds of formula I can be prepared in high purity and yield. In the chemical formula, R 1 and R 2 are protecting groups, and each independently represents benzoyl, 4-methylbenzoyl, 3-methylbenzoyl, 4-cyanobenzoyl, 3-cyanobenzoyl, 4-propylbenzoyl, 2-ethoxybenzoyl, 4-t-butylbenzoyl, 1-naphthoyl or 2-naphthoyl, R 3 , R 4 and R 7 are each independently C 1 -C 3 alkyl, R 5 is methyl or ethyl, R 6 Is hydrogen, methyl or methoxy. |
| priorityDate | 2007-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.